解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:The variability in gene organization and architecture of green algal mitochondrial genomes is only recently being studied on a finer taxonomic scale. Sequenced mt genomes from the chlorophycean orders Volvocales and Sphaeropleales exhibit considerable variation in size, content, and structure, even among clo...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-2056-5
更新日期:2015-10-21 00:00:00
abstract:BACKGROUND:Urechis unicinctus, an echiuran worm inhabiting the U-shaped burrows in the coastal mud flats, is an important commercial and ecological invertebrate in Northeast Asian countries, which has potential applications in the study of animal evolution, coastal sediment improvement and marine drug development. Furt...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-2094-z
更新日期:2015-10-21 00:00:00
abstract:BACKGROUND:Variation in environment, management practices, nutrition or selection objectives has led to a variety of different choices being made in the use of genetic material between countries. Differences in genome-level homozygosity between countries may give rise to regions that result in inbreeding depression to ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-2001-7
更新日期:2015-10-19 00:00:00
abstract:BACKGROUND:Long non-coding RNAs (lncRNAs) are a new class of regulatory molecules with roles in diverse biological processes. While much effort has been invested in the analysis of lncRNAs from established plant models Arabidopsis, maize, and rice, almost nothing is known about lncRNAs from fruit crops, including those...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-2014-2
更新日期:2015-10-19 00:00:00
abstract:BACKGROUND:Simple Sequence Repeats (SSRs) are widely used in population genetic studies but their classical development is costly and time-consuming. The ever-increasing available DNA datasets generated by high-throughput techniques offer an inexpensive alternative for SSRs discovery. Expressed Sequence Tags (ESTs) hav...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-2031-1
更新日期:2015-10-13 00:00:00
abstract:BACKGROUND:The capacity of European pear fruit (Pyrus communis L.) to ripen after harvest develops during the final stages of growth on the tree. The objective of this study was to characterize changes in 'Bartlett' pear fruit physico-chemical properties and transcription profiles during fruit maturation leading to att...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-1939-9
更新日期:2015-10-09 00:00:00
abstract:BACKGROUND:Laminitis, the structural failure of interdigitated tissue that suspends the distal skeleton within the hoof capsule, is a devastating disease that is the second leading cause of both lameness and euthanasia in the horse. Current transcriptomic research focuses on the expression of known genes. However, as t...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-1948-8
更新日期:2015-10-03 00:00:00
abstract:BACKGROUND:Glutamine is a major amino donor for the synthesis of amino acids, nucleotides, and other nitrogen-containing compounds in all organisms. In addition to its role in nutrition and metabolism, glutamine can also function as a signaling molecule in bacteria, yeast, and humans. By contrast, the functions of glut...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-1892-7
更新日期:2015-09-25 00:00:00
abstract:BACKGROUND:There are no commercially available vaccines against human protozoan parasitic diseases, despite the success of vaccination-induced long-term protection against infectious diseases. East Coast fever, caused by the protist Theileria parva, kills one million cattle each year in sub-Saharan Africa, and contribu...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-1910-9
更新日期:2015-09-24 00:00:00
abstract:BACKGROUND:Wheat stripe rust, caused by Puccinia striiformis f. sp. tritici, is a costly global disease that burdens farmers with yield loss and high fungicide expenses. This sophisticated biotrophic parasite infiltrates wheat leaves and develops infection structures inside host cells, appropriating nutrients while sup...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-1895-4
更新日期:2015-09-21 00:00:00
abstract:BACKGROUND:Salmonella Typhimurium is frequently isolated from foodborne infection cases in Hong Kong, but the lack of genome sequences has hindered in-depth epidemiological and phylogenetic studies. In this study, we sought to reconstruct the phylogenetic relationship and investigate the distribution and mutation patte...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-1900-y
更新日期:2015-09-14 00:00:00
abstract:BACKGROUND:Insertion sequences (IS) are small transposable elements, commonly found in bacterial genomes. Identifying the location of IS in bacterial genomes can be useful for a variety of purposes including epidemiological tracking and predicting antibiotic resistance. However IS are commonly present in multiple copie...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-1860-2
更新日期:2015-09-03 00:00:00
abstract:BACKGROUND:The host response to influenza A infections is strongly influenced by host genetic factors. Animal models of genetically diverse mouse strains are well suited to identify host genes involved in severe pathology, viral replication and immune responses. Here, we have utilized a dual RNAseq approach that allowe...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-1867-8
更新日期:2015-09-02 00:00:00
abstract:BACKGROUND:Butterflies and moths are emerging as model organisms in genetics and evolutionary studies. The family Hesperiidae (skippers) was traditionally viewed as a sister to other butterflies based on its moth-like morphology and darting flight habits with fast wing beats. However, DNA studies suggest that the famil...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-1846-0
更新日期:2015-08-27 00:00:00
abstract:BACKGROUND:Invasive aspergillosis is started after germination of Aspergillus fumigatus conidia that are inhaled by susceptible individuals. Fungal hyphae can grow in the lung through the epithelial tissue and disseminate hematogenously to invade into other organs. Low fungaemia indicates that fungal elements do not re...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-1853-1
更新日期:2015-08-27 00:00:00
abstract:BACKGROUND:Prokaryotic translation initiation involves the proper docking, anchoring, and accommodation of mRNA to the 30S ribosomal subunit. Three initiation factors (IF1, IF2, and IF3) and some ribosomal proteins mediate the assembly and activation of the translation initiation complex. Although the interaction betwe...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-1808-6
更新日期:2015-08-14 00:00:00
abstract:BACKGROUND:Haloquadratum walsbyi represents up to 80% of cells in NaCl-saturated brines worldwide, but is notoriously difficult to maintain under laboratory conditions. In order to establish the extent of genetic diversity in a natural population of this microbe, we screened a H. walsbyi enriched metagenomic fosmid lib...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-1794-8
更新日期:2015-08-13 00:00:00
abstract:BACKGROUND:A systems toxicology investigation comparing and integrating transcriptomic and proteomic results was conducted to develop holistic effects characterizations for the wildlife bird model, Northern bobwhite (Colinus virginianus) dosed with the explosives degradation product 2-amino-4,6-dinitrotoluene (2A-DNT)....
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-1798-4
更新日期:2015-08-07 00:00:00
abstract:BACKGROUND:Color polymorphism in the nacre of pteriomorphian bivalves is of great interest for the pearl culture industry. The nacreous layer of the Polynesian black-lipped pearl oyster Pinctada margaritifera exhibits a large array of color variation among individuals including reflections of blue, green, yellow and pi...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-1776-x
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:The environmental light-dark cycle is the dominant cue that maintains 24-h biological rhythms in multicellular organisms. In Drosophila, light entrainment is mediated by the photosensitive protein CRYPTOCHROME, but the role and extent of transcription regulation in light resetting of the dipteran clock is ye...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-1787-7
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:Small insertions and deletions (InDels) constitute the second most abundant class of genetic variants and have been found to be associated with many traits and diseases. The present study reports on the detection and characterisation of about 883 K high quality InDels from the whole-genome analysis of severa...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-1711-1
更新日期:2015-07-31 00:00:00
abstract:BACKGROUND:Mango fruits contain a broad spectrum of phenolic compounds which impart potential health benefits; their biosynthesis is catalysed by enzymes in the phenylpropanoid-flavonoid (PF) pathway. The aim of this study was to reveal the variability in genes involved in the PF pathway in three different mango variet...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-1784-x
更新日期:2015-07-30 00:00:00
abstract:BACKGROUND:Trifoliate orange (Poncirus trifoliata (L.) Raf.) is extremely cold hardy after a full acclimation; however the underlying molecular mechanisms underlying this economically valuable trait remain poorly understood. In this study, global transcriptome profiles of trifoliate orange under cold conditions (4 °C) ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-1629-7
更新日期:2015-07-29 00:00:00
abstract:BACKGROUND:Major secondary metabolites, including flavonoids, caffeine, and theanine, are important components of tea products and are closely related to the taste, flavor, and health benefits of tea. Secondary metabolite biosynthesis in Camellia sinensis is differentially regulated in different tissues during growth a...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-1773-0
更新日期:2015-07-29 00:00:00
abstract:BACKGROUND:One of the most important global pathogens infecting all age groups is Streptococcus pneumoniae (the 'pneumococcus'). Pneumococci reside in the paediatric nasopharynx, where they compete for space and resources, and one competition strategy is to produce a bacteriocin (antimicrobial peptide or protein) to at...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-1729-4
更新日期:2015-07-28 00:00:00
abstract:BACKGROUND:Wine produced at low temperature is often considered to improve sensory qualities. However, there are certain drawbacks to low temperature fermentations: e.g. low growth rate, long lag phase, and sluggish or stuck fermentations. Selection and development of new Saccharomyces cerevisiae strains well adapted a...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-1755-2
更新日期:2015-07-22 00:00:00
abstract:BACKGROUND:Serine/threonine kinase 33 (STK33) has been shown to be conserved across all major vertebrate classes including reptiles, mammals, amphibians and fish, suggesting its importance within vertebrates. It has been shown to phosphorylate vimentin and might play a role in spermatogenesis and organ ontogenesis. In ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-1769-9
更新日期:2015-07-22 00:00:00
abstract:BACKGROUND:Sweet sorghum is an annual C4 crop considered to be one of the most promising bio-energy crops due to its high sugar content in stem, yet it is poorly understood how this plant increases its sugar content in response to salt stress. In response to high NaCl, many of its major processes, such as photosynthesi...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-1760-5
更新日期:2015-07-19 00:00:00
abstract:BACKGROUND:Genome-wide association studies show that most human traits and diseases are caused by a combination of environmental and genetic causes, with each one of these having a relatively small effect. In contrast, most therapies based on macromolecules like antibodies, antisense oligonucleotides or peptides focus ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-1727-6
更新日期:2015-07-18 00:00:00
abstract:BACKGROUND:Most microbial eukaryotes are uncultivated and thus poorly suited to standard genomic techniques. This is the case for Polykrikos lebouriae, a dinoflagellate with ultrastructurally aberrant plastids. It has been suggested that these plastids stem from a novel symbiosis with either a diatom or haptophyte, but...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-1636-8
更新日期:2015-07-17 00:00:00
abstract:BACKGROUND:Lateral gene transfer (LGT) is an important evolutionary process in microbial evolution. In sewage treatment plants, LGT of antibiotic resistance and xenobiotic degradation-related proteins has been suggested, but the role of LGT outside these processes is unknown. Microbial communities involved in Enhanced ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-1752-5
更新日期:2015-07-16 00:00:00
abstract:BACKGROUND:The Xanthomonas citri pv. citri (X. citri) is a phytopathogenic bacterium that infects different species of citrus plants where it causes canker disease. The adaptation to different habitats is related to the ability of the cells to metabolize and to assimilate diverse compounds, including sulfur, an essenti...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-1736-5
更新日期:2015-07-14 00:00:00
abstract:BACKGROUND:Laboratory evolution is an important tool for developing robust yeast strains for bioethanol production since the biological basis behind combined tolerance requires complex alterations whose proper regulation is difficult to achieve by rational metabolic engineering. Previously, we reported on the evolved i...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-1737-4
更新日期:2015-07-09 00:00:00
abstract:BACKGROUND:The formation of flowers is one of the main model systems to elucidate the molecular mechanisms that control developmental processes in plants. Although several studies have explored gene expression during flower development in the model plant Arabidopsis thaliana on a genome-wide scale, a continuous series ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-1699-6
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:Triptolide is a therapeutic diterpenoid derived from the Chinese herb Tripterygium wilfordii Hook f. Triptolide has been shown to induce apoptosis by activation of pro-apoptotic proteins, inhibiting NFkB and c-KIT pathways, suppressing the Jak2 transcription, activating MAPK8/JNK signaling and modulating the...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-1614-1
更新日期:2015-06-30 00:00:00
abstract:BACKGROUND:Floral transition is a critical event in the life cycle of a flowering plant as it determines its reproductive success. Despite extensive studies of specific genes that regulate this process, the global changes in transcript expression profiles at the point when a vegetative meristem transitions into an infl...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-1688-9
更新日期:2015-06-18 00:00:00
abstract:BACKGROUND:Various saprotrophic microorganisms, especially filamentous fungi, can efficiently degrade lignocellulose that is one of the most abundant natural materials on earth. It consists of complex carbohydrates and aromatic polymers found in the plant cell wall and thus in plant debris. Aspergillus fumigatus Z5 was...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-1658-2
更新日期:2015-06-16 00:00:00
abstract:BACKGROUND:Insect mitochondrial genomes (mitogenomes) are the most extensively used genetic marker for evolutionary and population genetics studies of insects. The Pentatomoidea superfamily is economically important and the largest superfamily within Pentatomomorpha with over 7,000 species. To better understand the div...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-1679-x
更新日期:2015-06-16 00:00:00
abstract:BACKGROUND:The substantially large bread wheat genome, organized into highly similar three sub-genomes, renders genomic research challenging. The construction of BAC-based physical maps of individual chromosomes reduces the complexity of this allohexaploid genome, enables elucidation of gene space and evolutionary rela...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-1641-y
更新日期:2015-06-13 00:00:00
abstract:BACKGROUND:Banana and plantain (Musa spp.) comprise an important part of diets for millions of people around the globe. Low temperature is one of the key environmental stresses which greatly affects the global banana production. To understand the molecular mechanism of the cold-tolerance in plantain we used RNA-Seq bas...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-1551-z
更新日期:2015-06-10 00:00:00